Hydrochloric Acid → HCID 22245967, compound

HRID 1179031Notes

Reaction equation

HRID 1179031 reaction equation
[CH2:1]([NH:8][CH:9]1[CH2:14][CH2:13][C:12]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)([N:15]([CH3:17])[CH3:16])[CH2:11][CH2:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.O.[Cl:26][Si](C)(C)C>CC(=O)CC>[ClH:26].[CH2:1]([NH:8][CH:9]1[CH2:14][CH2:13][C:12]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)([N:15]([CH3:17])[CH3:16])[CH2:11][CH2:10]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 6397ChlorotrimethylsilaneHCID 9922658HCID 9922658, compound

Product 1

HCID 22245967HCID 22245967, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

As described for example 1, 1.01 g of the polar diastereomer of N′-benzyl-N,N-dimethyl-1-phenyl-cyclohexane-1,4-diamine were also obtained, and were converted into 781 mg of the corresponding hydrochloride by dissolving in 8.1 ml 2-butanone and addition of 32.5 μl water followed by 457 μl chlorotrimethylsilane and stirring overnight.

Workup

  1. customwere also obtained

Sources & evidence

ORD record
ord-985ee61c9d9a478dbef2f793d7d5d5a9
Source dataset
uspto-grants-2007_10
Patent number
US07276518B2

Reaction notes

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