Hydrochloric Acid → HCID 86591660, compound

HRID 1179342Notes

Reaction equation

HRID 1179342 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[NH:10][CH2:11][CH2:12][CH2:13][NH:14][C:15](=[O:33])[CH2:16][N:17]1[CH2:23][CH2:22][CH:21]([CH2:24][C:25]([O-:27])=[O:26])[C:20]2[CH:28]=[CH:29][CH:30]=[CH:31][C:19]=2[C:18]1=[O:32].[ClH:34]>C(O)(=O)C.O1CCOCC1.O>[ClH:34].[C:25]([CH2:24][CH:21]1[C:20]2[CH:28]=[CH:29][CH:30]=[CH:31][C:19]=2[C:18](=[O:32])[N:17]([CH2:16][C:15]([NH:14][CH2:13][CH2:12][CH2:11][NH:10][C:2]2[NH:1][C:5]3[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=3[N:3]=2)=[O:33])[CH2:23][CH2:22]1)([OH:27])=[O:26]

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 86591662HCID 86591662, compound

Product 1

HCID 86591660HCID 86591660, compound

Reagents, catalysts & solvents 3

HCID 176Acetic AcidSolventHCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

Analogously to Example II, the tert-butyl ester (Example IX) in glacial acetic acid was cleaved using 4N HCl in dioxane. After stripping off the solvent, the residue was dissolved in water, clarified with active carbon and then lyophilized; 0.72 g of white amorphous residue; ESI-MS [M+H+]: 450.

Sources & evidence

ORD record
ord-5428248e84094ce0bc6d07d385d287da
Source dataset
uspto-grants-2007_10
Patent number
US07279468B2

Reaction notes

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