反应详情

To a solution of the product of Example 2 (2.0 g) in DCM (40 mL) was added pyrrolidine (1.0 g) followed by sodium triacetoxyborohydride (2.8 g). The resulting mixture was stirred overnight, and treated with 10% NaOH (20 mL). The resulting mixture was extracted with DCM (300 mL). The combined extracts were washed with water (50 mL) and brine (50 mL), dried (MgSO4), and concentrated under reduced pressure to give the title compound as a light pink-brown oil (2.4 g).

1. extractionThe resulting mixture was extracted with DCM (300 mL)
2. washThe combined extracts were washed with water (50 mL) and brine (50 mL)
3. dry with materialdried (MgSO4)
4. concentrationconcentrated under reduced pressure