Sodium Hydroxide → HCID 58978028, compound

HRID 1179355Notes

Reaction equation

HRID 1179355 reaction equation
[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([N:14]3[CH2:23][CH2:22][C:17]4(OCC[O:18]4)[CH2:16][CH2:15]3)=[CH:10][CH:9]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[OH-].[Na+]>Cl>[N:1]1([CH2:7][C:8]2[CH:9]=[CH:10][C:11]([N:14]3[CH2:15][CH2:16][C:17](=[O:18])[CH2:22][CH2:23]3)=[CH:12][CH:13]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 58978022HCID 58978022, compound

Product 1

HCID 58978028HCID 58978028, compoundYield 110.9%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
100 °C

Procedure

The product of Example 14 (4.5 g) was treated with 6 M HCl (50 mL), heated to 100° C. for 90 min, and then cooled to room temperature. The resulting solution was basified with 10% aqueous NaOH to pH 11, and extracted with DCM (3×5 mL). The combined extracts were dried (MgSO4), and concentrated under reduced pressure, giving the title compound as a brown gummy solid (4.3 g).

Workup

  1. temperaturecooled to room temperature
  2. extractionextracted with DCM (3×5 mL)
  3. dry with materialThe combined extracts were dried (MgSO4)
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-799b7b22d5dd420b9feb9a44aa123719
Source dataset
uspto-grants-2007_10
Patent number
US07279491B2

Reaction notes

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