Succinic anhydride → HCID 22047951, compound

HRID 1179693Notes

Reaction equation

HRID 1179693 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][CH3:9])=[N:6][CH:7]=1.[C:10]1(=O)[O:15][C:13](=[O:14])[CH2:12][CH2:11]1>>[CH3:9][O:8][C:5]1[N:6]=[CH:7][C:2]([N:1]2[C:13](=[O:14])[CH2:12][CH2:11][C:10]2=[O:15])=[CH:3][CH:4]=1

Participants

3

Reactant 2

HCID 7922Succinic anhydrideHCID 811216-Methoxy-3-pyridinylamine

Product 1

HCID 22047951HCID 22047951, compound

Procedure

A mixture of 5-amino-2-methoxypyridine (1.24 g, 10.0 mmol) and succinic anhydride (1.00 g, 10.0 mmol) was heated with a heat gun for 10 minutes. After cooling to room temperature the product was purified by flash column chromatography (SiO2, ethyl acetate:acetone 25:75). Evaporation of the solvent yielded the title compound as a white solid.

Workup

  1. temperaturewas heated with a heat gun for 10 minutes
  2. customwas purified by flash column chromatography (SiO2, ethyl acetate:acetone 25:75)
  3. customEvaporation of the solvent

Sources & evidence

ORD record
ord-0cb5bcb87a574e8596cb7477b50c5c6d
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

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