4-(5-Trifluoromethylpyridin-2-yloxy)-phenyl chloroformate → HCID 69518109, compound

HRID 1179993Notes

Reaction equation

HRID 1179993 reaction equation
Cl.Cl.[CH:3]([N:6]([CH3:13])[CH:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1)([CH3:5])[CH3:4].Cl[C:15]([O:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][C:25]2[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][N:26]=2)=[CH:20][CH:19]=1)=[O:16]>CN(C)C=O>[F:33][C:31]([F:32])([F:34])[C:28]1[CH:29]=[CH:30][C:25]([O:24][C:21]2[CH:22]=[CH:23][C:18]([O:17][C:15]([N:10]3[CH2:9][CH2:8][CH:7]([N:6]([CH:3]([CH3:5])[CH3:4])[CH3:13])[CH2:12][CH2:11]3)=[O:16])=[CH:19][CH:20]=2)=[N:26][CH:27]=1

Participants

4

Reactant 2

HCID 220477624-(5-Trifluoromethylpyridin-2-yloxy)-phenyl chloroformateHCID 45791934HCID 45791934, compound

Product 1

HCID 69518109HCID 69518109, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title product was prepared from isopropyl-methyl-piperidin-4-yl-amine, dihydrochloride and 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate; dimethylformamide as solvent, preparative HPLC (method C) (77%, light yellow oil). HPLC-MS m/z=438.3 (M+1), Rt: 2.77 min.

Sources & evidence

ORD record
ord-1872073473df436db8b131e6987c864a
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

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