Water → HCID 86584164, compound

Temperature

0 °C

To a 12 L 3-neck round bottom flask was added isopropyl acetate (6.5 L). The solvent was cooled to 0° C. in an ice-water bath and 3-amino-1-propanol (1.14 Kg, 15.1 mol, 2.15 eq) was added in one portion. To this rapidly stirring solution, benzyl chloroformate (1.20 Kg, 7.03 mol, 1.0 eq) was added dropwise over 2 h while maintaining the internal temperature of the flask between 10° C. and 15° C. After the addition was complete, the reaction mixture was allowed to stir between 10° C. and 15° C. for an additional 0.3 h after which time water (3.5 L) was added in one portion. The solution was then partitioned and washed with an additional 2×3.5 L of water. The organic layer was dried over potassium carbonate and concentrated to give a solid that was dissolved in excess isopropyl acetate and precipitated from solution by adding the compound to heptane. The solid was filtered under nitrogen to yield 1.20 Kg (82%) of the desired product as a colorless solid.

1. temperaturewhile maintaining the internal temperature of the flask between 10° C. and 15° C
2. additionAfter the addition
3. additionwas added in one portion
4. customThe solution was then partitioned
5. washwashed with an additional 2×3.5 L of water
6. dry with materialThe organic layer was dried over potassium carbonate
7. concentrationconcentrated
8. customto give a solid
9. customprecipitated from solution
10. additionby adding the compound to heptane
11. filtrationThe solid was filtered under nitrogen

ORD record

ord-10daa68ebe2349c3bb108fee3d22923f

Source dataset

uspto-grants-2007_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07279582B2