Hydroxyamine hydrochloride → HCID 86618214, compound

HRID 1180331Notes

Reaction equation

HRID 1180331 reaction equation
[Si:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([CH:21]=O)=[C:17]([Cl:23])[CH:16]=2)=[CH:11][CH:10]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].Cl.[NH2:25][OH:26]>>[Si:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([CH:21]=[N:25][OH:26])=[C:17]([Cl:23])[CH:16]=2)=[CH:11][CH:10]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 86618215HCID 86618215, compound

Product 1

HCID 86618214HCID 86618214, compound

Procedure

The title compound was prepared by reacting 4′-{[tert-butyl(dimethyl)silyl]oxy}-3-chloro-1,1′-biphenyl-4-carbaldehyde (405 mg, 1.17 mmol) with hydroxylamine hydrochloride (154 mg, 2.22 mmol) according to Method C to yield a yellowish oil which was used in the next step without purification: MS (ESI) m/z 362/364 (M+H)+.

Workup

  1. customto yield a yellowish oil which
  2. customwas used in the next step without purification

Sources & evidence

ORD record
ord-fbdc00e75e824360a105e18abb94ab94
Source dataset
uspto-grants-2007_10
Patent number
US07279600B2

Reaction notes

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