Hydroxyamine hydrochloride → HCID 86596213, compound

HRID 1180332Notes

Reaction equation

HRID 1180332 reaction equation
[Si:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([CH:21]=O)=[CH:17][C:16]=2[F:23])=[CH:11][CH:10]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].Cl.[NH2:25][OH:26]>>[Si:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([CH:21]=[N:25][OH:26])=[CH:17][C:16]=2[F:23])=[CH:11][CH:10]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 86596214HCID 86596214, compound

Product 1

HCID 86596213HCID 86596213, compound

Procedure

The title compound was prepared by reacting 4′-{[tert-butyl(dimethyl)silyl]oxy}-2-fluoro-1,1′-biphenyl-4-carbaldehyde (450 mg, 1.36 mmol) with hydroxylamine hydrochloride (190 mg, 2.73 mmol) according to Method C to yield a white solid which was used in the next step without purification: MS (ESI) m/z 344 (M−H)−, 346 (M+H)+.

Workup

  1. customto yield a white solid which
  2. customwas used in the next step without purification

Sources & evidence

ORD record
ord-b8f463a9aee4446188883514cadd6f8e
Source dataset
uspto-grants-2007_10
Patent number
US07279600B2

Reaction notes

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