4-Bromo-2-fluorobenzaldehyde → HCID 23005036, compound

HRID 1180333Notes

Reaction equation

HRID 1180333 reaction equation
Br[C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4]([F:10])[CH:3]=1.[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16](B(O)O)=[CH:15][CH:14]=1>>[F:10][C:4]1[CH:3]=[C:2]([C:16]2[CH:17]=[CH:18][C:13]([O:12][CH3:11])=[CH:14][CH:15]=2)[CH:9]=[CH:8][C:5]=1[CH:6]=[O:7]

Participants

3

Reactant 2

HCID 1435174-Bromo-2-fluorobenzaldehydeHCID 201262(4-Methoxyphenyl)boronic acid

Product 1

HCID 23005036HCID 23005036, compound

Procedure

The title compound was prepared by reacting 4-bromo-2-fluoro-benzaldehyde (3 g, 14.8 mmol) with 4-methoxyphenylboronic acid (2.70 g, 17.8 mmol) according to Method B to yield 3.2 g (94%) of white solid: mp 85-86° C.; 1H NMR (DMSO-d6): δ 3.83 (3H, s). 7.06-7.09 (2H, m), 7.70-7.75 (2H, m), 7.79-7.82 (2H, m), 7.88 (1H, t, J=7.96 Hz), 10.22 (1H, s); IR 1681 cm−1; MS (ESI) m/z 231 (M+H)+.

Sources & evidence

ORD record
ord-d7cc0d44a65147779386dd33c4df0e18
Source dataset
uspto-grants-2007_10
Patent number
US07279600B2

Reaction notes

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