Hydroxyamine hydrochloride → HCID 136338596, compound

HRID 1180342Notes

Reaction equation

HRID 1180342 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([CH:14]=O)=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.Cl.[NH2:17][OH:18]>>[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([CH:14]=[N:17][OH:18])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 27592994-(4-hydroxyphenyl)benzaldehyde

Product 1

HCID 136338596HCID 136338596, compound

Procedure

The title compound was prepared by reacting 4′-hydroxy[1,1′-biphenyl]-4-carbaldehyde (1.03 mmol) with hydroxylamine hydrochloride (140 mg, 2 mmol) according to Method C to yield 193 mg (79%, over two steps) of yellowish solid: mp 207-210° C.; 1H NMR (DMSO-d6): δ 6.85 (2H, d, J=8.37 Hz), 7.53 (2H, d, J=8.39 Hz), 7.62 (4H, s), 8.15 (1H, s), 9.62 (1H, s), 11.21 (1H, s); MS (ESI) m/z 212 (M−H)−.

Workup

  1. customto yield 193 mg (79%, over two steps) of yellowish solid

Sources & evidence

ORD record
ord-f7db628c988047d1bfcee363798791db
Source dataset
uspto-grants-2007_10
Patent number
US07279600B2

Reaction notes

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