反应详情

温度

-78 °C

To a solution of 1,4-dibromobenzene (42.4 mmol, 10 g) in THF (100 mL) at −78° C. was added dropwise n-BuLi (42.4 mmol, 2 M in hexane). The mixture was stirred at −78° C. for 0.5 h., cyclohexanecarboxaldehyde (42.4 mmol, 4.8 g) was added. The mixture was stirred at −78° C. for 0.5 h and then warmed to r.t. The reaction mixture was diluted with EtOAc, washed with NaHCO3 and brine. The organic extract was dried (anhyd. MgSO4) and concentrated under reduced pressure to give an oil. Chromatography gave the title compound.

1. stirringThe mixture was stirred at −78° C. for 0.5 h
2. temperaturewarmed to r.t
3. washwashed with NaHCO3 and brine
4. extractionThe organic extract
5. dry with materialwas dried (anhyd. MgSO4)
6. concentrationconcentrated under reduced pressure
7. customto give an oil