反应详情

温度

-78 °C

To a solution of 4-brombenzaldehyde (27 mmol, 5.0 g) in THF (20 mL) was added at −78° C. a solution of isopropylmagnesium chloride (41 mmol, 20.2 mL, 2M in ether). The mixture was stirred at −78° C. for 1 h and warmed to 0° C. for 1 h. NH4Cl was added an the mixture was extracted with EtOAc. The organic extract was washed with brine, dried and concentrated to an oil. Chromatography (5-15% EtOAc/hexane) gave the desired alcohol.

1. temperaturewarmed to 0° C. for 1 h
2. extractionwas extracted with EtOAc
3. extractionThe organic extract
4. washwas washed with brine
5. customdried
6. concentrationconcentrated to an oil