反应详情

To a solution of 1 g (2.4 mmoles) of methyl 2-{[(4-bromophenyl)(phenyl)methyl]thio}-4-methylpentanoate from example 73 step 2 in a ternary mixture of tetrahydrofuran, methanol and water was added solid lithium hydroxyde monohydrate (151 mg, 3.6 mmoles). The reaction was stirred until disappearance of the starting material by thin layer chromatography and diluted with 1N hydrochloric acid and dichloromethane. The phases were separated and the aqueous phase was washed twice with dichloromethane. The combined organic layers were dried over magnesium sulfate and concentrated under reduced pressure. The title acid was used without further purification.

1. customThe phases were separated
2. washthe aqueous phase was washed twice with dichloromethane
3. dry with materialThe combined organic layers were dried over magnesium sulfate
4. concentrationconcentrated under reduced pressure
5. customThe title acid was used without further purification