Water → HCID 86588658, compound

HRID 1180547Notes

Reaction equation

HRID 1180547 reaction equation
[CH3:1][CH:2]([CH3:25])[CH:3]([N:8]([CH3:24])[S:9]([C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH:20]=[C:21]=[CH:22][CH3:23])=[CH:14][CH:13]=1)(=[O:11])=[O:10])[C:4]([O:6]C)=[O:5].[OH-].[Li+].O>O1CCCC1.CO>[CH3:24][N:8]([S:9]([C:12]1[CH:13]=[CH:14][C:15]([O:18][CH2:19][CH:20]=[C:21]=[CH:22][CH3:23])=[CH:16][CH:17]=1)(=[O:10])=[O:11])[C@H:3]([C:4]([OH:6])=[O:5])[CH:2]([CH3:25])[CH3:1]

Participants

6

Reactant 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 86588659HCID 86588659, compound

Product 1

HCID 86588658HCID 86588658, compoundYield 87.1%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

The procedure of Example 12 was followed using the product from Example 20 (240 mg, 0.65 mmol), and lithium hydroxide (31 mg, 1.31 mmol) in tetrahydrofuran (2 ml), methanol (2 ml), and water (1 ml) to give 200 mg (87%) of the product.

Sources & evidence

ORD record
ord-643e9766877b492988dcea4c390baffa
Source dataset
uspto-grants-2007_10
Patent number
US07282496B2

Reaction notes

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