p-Toluenesulfonic acid monohydrate → p-Toluenesulfonic acid

HRID 1180720Notes

Reaction equation

HRID 1180720 reaction equation
O.[C:2]1([CH3:12])[CH:7]=[CH:6][C:5]([S:8]([OH:11])(=[O:10])=[O:9])=[CH:4][CH:3]=1>C1(C)C=CC=CC=1>[C:2]1([CH3:12])[CH:3]=[CH:4][C:5]([S:8]([OH:11])(=[O:9])=[O:10])=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 521998p-Toluenesulfonic acid monohydrate

Product 1

HCID 6101p-Toluenesulfonic acidYield 2,027.1%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To this solution, 400 ml of toluene was added, and then 112.7 g (59.3 mmol, 1.0 eq) of p-toluenesulfonic acid monohydrate was added, and dissolved under heating. Then, the solution was cooled for crystallization, thereby obtaining 207 g (yield: 75%) of p-toluene sulfonic acid (PTS) salt of Exemplified compound (21).

Workup

  1. dissolutiondissolved
  2. temperatureunder heating
  3. temperatureThen, the solution was cooled for crystallization

Sources & evidence

ORD record
ord-cb0a4f8709c34ff3ad9d0c0277f6a1aa
Source dataset
uspto-grants-2007_10
Patent number
US07282610B2

Reaction notes

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