HCID 58979123, compound → HCID 58979222, compound

HRID 1181080Notes

Reaction equation

HRID 1181080 reaction equation
[CH3:1][O:2][C:3](=[O:29])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12]CC2C=CC=CC=2)=[C:8]([CH2:20][NH:21][C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH:7]=1>C1COCC1>[CH3:1][O:2][C:3](=[O:29])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[C:8]([CH2:20][NH:21][C:22]([O:24][C:25]([CH3:27])([CH3:26])[CH3:28])=[O:23])[CH:7]=1

Participants

3

Reactant 1

HCID 58979123HCID 58979123, compound

Product 1

HCID 58979222HCID 58979222, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 3-[4-benzyloxy-3-(tert-butoxycarbonylamino-methyl)-phenyl]-propionic acid methyl ester (8.50 g, 21.3 mmol) in THF (100 mL) was treated with 5% Pd-on-carbon (1.1 g) and shaken under a hydrogen atmosphere (60 psi) at ambient temperature for 6 h. The mixture was filtered through Celite and concentrated to a pale yellow solid (5.63 g, 85%).

Workup

  1. filtrationThe mixture was filtered through Celite
  2. concentrationconcentrated to a pale yellow solid (5.63 g, 85%)

Sources & evidence

ORD record
ord-3e57fbb893fd46e89caf5a88c6af2873
Source dataset
uspto-grants-2007_10
Patent number
US07282501B2

Reaction notes

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