反应详情

温度

80 °C

A solution of 2-bromo-5-hydroxy-benzaldehyde (5.99 g, 29.8 mmol, Preparation 13 Step A) in DMF (50 mL) was treated with benzyl bromide (7.65 g, 44.7 mmol) and Cs2CO3 (15.1 g, 44.7 mmol). The resulting mixture was heated at 80° C. for 60 min and was quenched with water (200 mL). The mixture was extracted with EtOAc (2×100 mL), dried (Na2SO4), and concentrated to a residue, which was purified on silica gel chromatography (hexanes/EtOAc 9/1) to afford 5-benzyloxy-2-bromo-benzaldehyde as white solid in quantitative yield.

1. customwas quenched with water (200 mL)
2. extractionThe mixture was extracted with EtOAc (2×100 mL)
3. dry with materialdried (Na2SO4)
4. concentrationconcentrated to a residue, which
5. customwas purified on silica gel chromatography (hexanes/EtOAc 9/1)