反应详情

温度

80 °C

To a solution of 3-(2-formyl-4-hydroxy-phenyl)-acrylic acid tert-butyl ester (4.97 g, 20.0 mmol) in DMF (40 mL) was added benzyl bromide (2.85 mL, 24.0 mmol) and Cs2CO3 (7.82 g, 24.0 mmol). The suspension was stirred at 80° C. for 30 min, and TLC indicated the reaction was complete. The mixture was quenched with H2O (500 mL) and extracted with EtOAc (2×100 mL). The combined organics were dried (Na2SO4) and concentrated to a residue, which was purified by silica gel chromatography (hexanes/EtOAc 9/1) to afford the title compound as yellow solid (6.70 g, 99%).

1. customThe mixture was quenched with H2O (500 mL)
2. extractionextracted with EtOAc (2×100 mL)
3. dry with materialThe combined organics were dried (Na2SO4)
4. concentrationconcentrated to a residue, which
5. customwas purified by silica gel chromatography (hexanes/EtOAc 9/1)