Triethylamine → HCID 54211444, compound

HRID 1181209Notes

Reaction equation

HRID 1181209 reaction equation
C(N(CC)CC)C.[Cl:8][C:9]1[N:17]=[CH:16][N:15]=[C:14]2[C:10]=1[N:11]=[C:12]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[OH:29])[N:13]2[CH2:18][C:19]([CH3:22])([CH3:21])[CH3:20].[P:30]([O-:37])([O:34][CH2:35][CH3:36])[O:31][CH2:32][CH3:33]>C(Cl)(Cl)(Cl)Cl>[P:30]([O:29][C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=1[C:12]1[N:13]([CH2:18][C:19]([CH3:22])([CH3:21])[CH3:20])[C:14]2[C:10]([N:11]=1)=[C:9]([Cl:8])[N:17]=[CH:16][N:15]=2)([O:34][CH2:35][CH3:36])([O:31][CH2:32][CH3:33])=[O:37]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 3780918DiethylphosphiteHCID 136186576HCID 136186576, compound

Product 1

HCID 54211444HCID 54211444, compound

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent

Procedure

Triethylamine (1.1 mmol) was added slowly to an ice-cooled solution of. 6-chloro-N9-neopentyl-8-(2-hydroxyphenyl)purine (1 mmol) and diethyl phosphite (1 mmol) in carbontetrachloride. The reaction was stirred at room temperature overnight. Triethylamine hydrochloride was precipitated as a white solid mass. Extraction and chromatography gave diethyl 2-(6-Chloro-N9-neopentylpurin-8-yl)phenyl phosphate.

Workup

  1. temperaturecooled solution of
  2. customTriethylamine hydrochloride was precipitated as a white solid mass
  3. extractionExtraction and chromatography

Sources & evidence

ORD record
ord-7dfcd6fa2bbc48269d168d5ee4ddecec
Source dataset
uspto-grants-2007_10
Patent number
US07285543B2

Reaction notes

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