反应详情

5-Methoxy-1H-pyrazole-3-carboxylic acid ethyl ester (120 mg, 0.71 mmol) was dissolved in tetrahydrofuran (THF) (2 mL). After addition of sodium hydroxide (2M in water; 1 mL) the mixture was stirred under reflux for 2 h. The reaction mixture was cooled to room temperature and acidified (pH 3) by addition of hydrochloric acid and extracted with ethyl acetate (3×20 ml). The extract was dried over sodium sulfate and evaporated to yield 86 mg (86%) of a white solid.

1. temperatureunder reflux for 2 h
2. extractionextracted with ethyl acetate (3×20 ml)
3. dry with materialThe extract was dried over sodium sulfate
4. customevaporated