N,N-Dimethylethylenediamine → 5-[2-(1-benzothien-3-ylmethyl)-7-isobutyl-5-methyl-4,6-dioxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-[2-(dimethylamino)ethyl]-1-methyl-1H-pyrrole-3-carboxamide

HRID 1181736Notes

Reaction equation

HRID 1181736 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][N:11]2[C:19]([C:20]3[N:24]([CH3:25])[CH:23]=[C:22]([C:26]([OH:28])=O)[CH:21]=3)=[C:18]3[C:13]([N:14]([CH2:32][CH:33]([CH3:35])[CH3:34])[C:15](=[O:31])[N:16]([CH3:30])[C:17]3=[O:29])=[N:12]2)=[CH:2]1.[CH3:36][N:37]([CH3:41])[CH2:38][CH2:39][NH2:40].C(P(=O)(OCC)OCC)#N>>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][N:11]2[C:19]([C:20]3[N:24]([CH3:25])[CH:23]=[C:22]([C:26]([NH:40][CH2:39][CH2:38][N:37]([CH3:41])[CH3:36])=[O:28])[CH:21]=3)=[C:18]3[C:13]([N:14]([CH2:32][CH:33]([CH3:35])[CH3:34])[C:15](=[O:31])[N:16]([CH3:30])[C:17]3=[O:29])=[N:12]2)=[CH:2]1

Participants

4

Reactant 3

HCID 66053N,N-DimethylethylenediamineHCID 76257Diethyl cyanophosphonateHCID 589809525-[2-(1-benzothien-3-ylmethyl)-7-isobutyl-5-methyl-4,6-dioxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-3-yl]-1-methyl-1H-pyrrole-3-carboxylic acid

Product 1

HCID 589809745-[2-(1-benzothien-3-ylmethyl)-7-isobutyl-5-methyl-4,6-dioxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-[2-(dimethylamino)ethyl]-1-methyl-1H-pyrrole-3-carboxamide

Procedure

This compound was synthesized by the reaction of 5-[2-(1-benzothien-3-ylmethyl)-7-isobutyl-5-methyl-4,6-dioxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-3-yl]-1-methyl-1H-pyrrole-3-carboxylic acid and N,N-dimethylethane-1,2-diamine using diethyl cyanophosphonate as a coupling reagent. Mass: 562.18 (M+H).

Sources & evidence

ORD record
ord-0fdbbe71eded4e3f87be8382f4ce0880
Source dataset
uspto-grants-2007_10
Patent number
US07285558B2

Reaction notes

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