4-(Chloromethyl)pyridinium chloride → 7-isobutyl-2-(1-naphthylmethyl)-3-pyridin-4-yl-5-(pyridin-4-ylmethyl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

HRID 1181765Notes

Reaction equation

HRID 1181765 reaction equation
[CH2:1]([N:5]1[C:10]2=[N:11][N:12]([CH2:20][C:21]3[C:30]4[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=4)[CH:24]=[CH:23][CH:22]=3)[C:13]([C:14]3[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=3)=[C:9]2[C:8](=[O:31])[NH:7][C:6]1=[O:32])[CH:2]([CH3:4])[CH3:3].Cl.Cl[CH2:35][C:36]1[CH:41]=[CH:40][N:39]=[CH:38][CH:37]=1.C1CCN2C(=NCCC2)CC1>>[CH2:1]([N:5]1[C:10]2=[N:11][N:12]([CH2:20][C:21]3[C:30]4[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=4)[CH:24]=[CH:23][CH:22]=3)[C:13]([C:14]3[CH:15]=[CH:16][N:17]=[CH:18][CH:19]=3)=[C:9]2[C:8](=[O:31])[N:7]([CH2:35][C:36]2[CH:41]=[CH:40][N:39]=[CH:38][CH:37]=2)[C:6]1=[O:32])[CH:2]([CH3:4])[CH3:3]

Participants

4

Reactant 3

HCID 745704-(Chloromethyl)pyridinium chlorideHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 694274457-isobutyl-2-(1-naphthylmethyl)-3-pyridin-4-yl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

Product 1

HCID 589810127-isobutyl-2-(1-naphthylmethyl)-3-pyridin-4-yl-5-(pyridin-4-ylmethyl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

Procedure

This compound was synthesized by the reaction of 7-isobutyl-2-(1-naphthylmethyl)-3-pyridin-4-yl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione and 4-(chloromethyl)pyridine hydrochloride using DBU as a base. Mass: 516.88 (M+H).

Sources & evidence

ORD record
ord-173de81ff3b246fc9625e322eba0a7fc
Source dataset
uspto-grants-2007_10
Patent number
US07285558B2

Reaction notes

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