Lithium Hydroxide → 7-(4-hydroxybenzyl)-5-methyl-2-(1-naphthylmethyl)-3-pyridin-4-yl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

HRID 1181774Notes

Reaction equation

C([O:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][N:12]2[C:17]3=[N:18][N:19]([CH2:27][C:28]4[C:37]5[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=5)[CH:31]=[CH:30][CH:29]=4)[C:20]([C:21]4[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=4)=[C:16]3[C:15](=[O:38])[N:14]([CH3:39])[C:13]2=[O:40])=[CH:7][CH:6]=1)(=O)C.[Li+].[OH-]>>[OH:4][C:5]1[CH:6]=[CH:7][C:8]([CH2:11][N:12]2[C:17]3=[N:18][N:19]([CH2:27][C:28]4[C:37]5[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=5)[CH:31]=[CH:30][CH:29]=4)[C:20]([C:21]4[CH:22]=[CH:23][N:24]=[CH:25][CH:26]=4)=[C:16]3[C:15](=[O:38])[N:14]([CH3:39])[C:13]2=[O:40])=[CH:9][CH:10]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 694280814-{[5-methyl-2-(1-naphthylmethyl)-4,6-dioxo-3-pyridin-4-yl-2,4,5,6-tetrahydro-7H-pyrazolo[3,4-d]pyrimidin-7-yl]methyl}phenyl acetate

Product 1

HCID 589809907-(4-hydroxybenzyl)-5-methyl-2-(1-naphthylmethyl)-3-pyridin-4-yl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

Procedure

This compound was synthesized by the hydrolysis of 4-{[5-methyl-2-(1-naphthylmethyl)-4,6-dioxo-3-pyridin-4-yl-2,4,5,6-tetrahydro-7H-pyrazolo[3,4-d]pyrimidin-7-yl]methyl}phenyl acetate with 0.5N LiOH at room temperature for six hours. Mass: 489.80 (M+H).

Sources & evidence

ORD record: ord-84292c1239ec42d7a11a5584b753e944
Source dataset: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07285558B2

Reaction notes

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