HRID1181790

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6367

Acetyl chloride

C2H3ClO

HCID11430

Potassium Carbonate

CK2O3

反应SMILES：Cc1sc(N)nc1-c1c2c(=O)n(C)c(=O)n(CC(C)C)c2nn1Cc1csc2ccccc12.Cl

HCID86595430

未命名化合物

PRODUCTS

产物

反应SMILES：CC(=O)Nc1nc(-c2c3c(=O)n(C)c(=O)n(CC(C)C)c3nn2Cc2csc3ccccc23)c(C)s1

HCID58981114

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8471

Triethylamine

C6H15N

PROCEDURE

实验过程

3-(2-amino-5-methyl-1,3-thiazol-4-yl)-2-(1-benzothien-3-ylmethyl)-7-isobutyl-5-methyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione hydrochloride was reacted with excess acetyl chloride using triethylamine as a base. The resulting bis acetylated product is treated with potassium carbonate to give the title compound. Mass: 523.22 (M+H).

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-ae002f5f98bf446a93a3ab9d4960ffb3
来源数据集: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US07285558B2
来源说明: uspto-grants-2007_10

反应SMILES

Cl.[NH2:2][C:3]1[S:4][C:5]([CH3:34])=[C:6]([C:8]2[N:9]([CH2:24][C:25]3[C:29]4[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=4[S:27][CH:26]=3)[N:10]=[C:11]3[C:16]=2[C:15](=[O:17])[N:14]([CH3:18])[C:13](=[O:19])[N:12]3[CH2:20][CH:21]([CH3:23])[CH3:22])[N:7]=1.[C:35](Cl)(=[O:37])[CH3:36].C(=O)([O-])[O-].[K+].[K+]>C(N(CC)CC)C>[S:27]1[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=2[C:25]([CH2:24][N:9]2[C:8]([C:6]3[N:7]=[C:3]([NH:2][C:35](=[O:37])[CH3:36])[S:4][C:5]=3[CH3:34])=[C:16]3[C:11]([N:12]([CH2:20][CH:21]([CH3:23])[CH3:22])[C:13](=[O:19])[N:14]([CH3:18])[C:15]3=[O:17])=[N:10]2)=[CH:26]1