Water → HCID 178481351, compound

HRID 1181842Notes

Reaction equation

HRID 1181842 reaction equation
[CH:1]1([CH2:4][N:5]2[C:10]([NH:11][NH2:12])=[CH:9][C:8](=[O:13])[N:7]([CH3:14])[C:6]2=[O:15])[CH2:3][CH2:2]1.O=P(Cl)(Cl)Cl.O.[CH3:22]N(C=O)C>>[CH:1]1([CH2:4][N:5]2[C:10]3=[N:11][NH:12][CH:22]=[C:9]3[C:8](=[O:13])[N:7]([CH3:14])[C:6]2=[O:15])[CH2:2][CH2:3]1

Participants

5

Reactant 4

HCID 962WaterHCID 6228DimethylformamideHCID 24813Phosphorus oxychlorideHCID 694271711-(cyclopropylmethyl)-6-hydrazino-3-methylpyrimidine-2,4(1H,3H)-dione

Product 1

HCID 178481351HCID 178481351, compound

Procedure

1-(Cyclopropylmethyl)-6-hydrazino-3-methylpyrimidine-2,4(1H,3H)-dione (5 g) was dissolved in DMF (5 mL) followed by addition of POCl3 (4 mL) dropwise at 0° C. The reaction was warmed to 80 C. for 3 h, followed by stirring at RT overnight. The solution was added to 200 mL of water and filtered to give about 5 g of yellow solids. Proton NMR was sufficient to carry on to next step.

Workup

  1. temperatureThe reaction was warmed to 80 C
  2. filtrationfiltered

Sources & evidence

ORD record
ord-3f20285246eb4c39b3ffd59d0c7ca946
Source dataset
uspto-grants-2007_10
Patent number
US07285558B2

Reaction notes

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