Trifluoroacetic acid → HCID 59643717, compound

HRID 1182250Notes

Reaction equation

HRID 1182250 reaction equation
[Cl:1][C:2]1[C:3]([OH:34])=[C:4]([S:9]([NH:12][C:13]2[CH:27]=[CH:26][CH:25]=[C:24]([N:28]3[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]3)[C:14]=2[CH2:15][NH:16]C(=O)OC(C)(C)C)(=[O:11])=[O:10])[CH:5]=[C:6]([Cl:8])[CH:7]=1.C(O)(C(F)(F)F)=O>ClCCl>[NH2:16][CH2:15][C:14]1[C:24]([N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[CH:25][CH:26]=[CH:27][C:13]=1[NH:12][S:9]([C:4]1[CH:5]=[C:6]([Cl:8])[CH:7]=[C:2]([Cl:1])[C:3]=1[OH:34])(=[O:11])=[O:10]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59643727HCID 59643727, compound

Product 1

HCID 59643717HCID 59643717, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 47 (75 mg) in dichloromethane (5 mL) was added TFA (0.5 mL). The solution was stirred overnight. Followed by usual workup. The title compound was obtained as an off-white solid (35 mg).

Sources & evidence

ORD record
ord-d2d24c2b46c04486a30897f8c997ac00
Source dataset
uspto-grants-2007_10
Patent number
US07288538B2

Reaction notes

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