Potassium Carbonate → HCID 22725247, compound

HRID 1182346Notes

Reaction equation

HRID 1182346 reaction equation
[C:1]1([C:7]2[C:8]3[CH2:9][CH2:10][NH:11][CH2:12][C:13]=3[C:14]3[NH:19][C:18](=[O:20])[C:17](=[O:21])[C:15]=3[CH:16]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:22][O:23][C:24](=[O:27])[CH2:25]Br.C(=O)([O-])[O-].[K+].[K+]>CO>[CH3:22][O:23][C:24]([CH2:25][N:11]1[CH2:10][CH2:9][C:8]2[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)=[CH:16][C:15]3[C:17](=[O:21])[C:18](=[O:20])[NH:19][C:14]=3[C:13]=2[CH2:12]1)=[O:27]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 22725243HCID 22725243, compound

Product 1

HCID 22725247HCID 22725247, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of 5-phenyl-6,7,8,9-tetrahydro-1H-pyrrolo[3,2-h]-isoquinoline-2,3-dione (0.278 g), methylbromoacetat (107.35 μl) and potassium carbonate (0.138 g) in methanol (20 ml) was stirred at room temperature for 24 hours. The suspension was partly evaporated and water (20 ml) was added. This afforded a solid precipitate which was collected by filtration.

Workup

  1. customThe suspension was partly evaporated
  2. additionwater (20 ml) was added
  3. customThis afforded a solid precipitate which
  4. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-55db5b543af6469bb42d83acfeaea41e
Source dataset
uspto-grants-2007_10
Patent number
US07288653B2

Reaction notes

Loading…