反应详情

1.2 g of sodium hydride at 50% in suspension in oil are added at 5° C., in portions, to 5 g of cyclohexanol in solution in 150 ml of dimethylformamide. The mixture is stirred for 1 hour at room temperature and 12.5 g of 2-bromobenzyl bromide in solution in 15 ml of dimethylformamide are introduced at 5° C. After 2 hours at room temperature, the reaction medium is poured over ice-cold water and extracted with ethyl acetate. The organic phase is dried over anhydrous sodium sulfate and evaporated to give 13.3 g of oil.

1. waitAfter 2 hours at room temperature
2. additionthe reaction medium is poured over ice-cold water
3. extractionextracted with ethyl acetate
4. dry with materialThe organic phase is dried over anhydrous sodium sulfate
5. customevaporated