Hydroxyamine hydrochloride → HCID 11120992, compound

HRID 1182469Notes

Reaction equation

HRID 1182469 reaction equation
[Br:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14](O)=[O:15])=[O:7])=[CH:4][CH:3]=1.[NH2:19][OH:20].Cl>C(N(CC)CC)C>[OH:20][NH:19][C:14](=[O:15])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][C:6](=[O:7])[C:5]1[CH:17]=[CH:18][C:2]([Br:1])=[CH:3][CH:4]=1

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 110014838-(4-BROMOPHENYL)-8-OXOOCTANOIC ACID

Product 1

HCID 11120992HCID 11120992, compoundYield 31%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Following the procedure described in Example 14, step 3, but substituting carboxylic acid 50d for 37 and using 1.1 equivalent of NH2OH.HCl and triethylamine each, the title compound was obtained as light yellow solid in 31% yield: 1H NMR (300 MHz, CD3OD/CDCl3=5/1) δ 7.82 (d, J=7.5 Hz, 2H), 7.62 (d, J=7.5 Hz, 2H), 2.95 (t, J=7.2 Hz, 2H), 2.11 (m, 2H), 1.55-1.79 (m, 4H), 1.38 (m, 4H).

Sources & evidence

ORD record
ord-bf8841593b5d410b891df2385b331409
Source dataset
uspto-grants-2007_10
Patent number
US07288567B2

Reaction notes

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