HRID1182515
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
Following the procedure described in Example 14, step 3, but substituting carboxylic acid 228b for 37, and using 1.1 equivalent of NH2OH.HCl and triethylamine each, the title compound 228b was obtained in 52% yield. 1H NMR: (300 MHz, DMSO-d6) δ 10.37 (s, 1H), 8.70 (s, 1H), 8.11 (d, J=8.5 Hz, 2H), 7.86 (d, J=8.5 Hz, 2H), 7.77 (dd, J=1.4 Hz, J=8.5 Hz, 2H), 7.53-7.43 (m, 3H), 5.08 (s, 2H), 3.38-3.25 (t, 2H), 1.99 (t, J=6.6 Hz, 2H), 1.72-1.61 (m, 4H).
WORKUP
后处理
- customwas obtained in 52% yield