Hydrochloric Acid → HCID 86590785, compound

HRID 1182590Notes

Reaction equation

HRID 1182590 reaction equation
C(CC[O:5][C:6]([C:8]1[CH:13]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([Cl:20])[CH:15]=2)[C:12]([C:21](=[O:38])[NH:22][CH2:23][CH2:24][CH:25]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[C:11]([CH2:39][O:40][CH2:41][CH2:42][N:43]=[N+:44]=[N-:45])[NH:10][C:9]=1[CH3:46])=[O:7])#N.[OH-].[Na+].Cl.O>CO>[N:43]([CH2:42][CH2:41][O:40][CH2:39][C:11]1[NH:10][C:9]([CH3:46])=[C:8]([C:6]([OH:7])=[O:5])[CH:13]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([Cl:20])[CH:15]=2)[C:12]=1[C:21](=[O:38])[NH:22][CH2:23][CH2:24][CH:25]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)=[N+:44]=[N-:45]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 86590784HCID 86590784, compound

Product 1

HCID 86590785HCID 86590785, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

250 mg (0.390 mmol) of 6-(2-azidoethoxy) methyl-4-(3-chlorophenyl)-5-(3,3-diphenylpropylcarbamoyl)-2-methyl-1,4-dihydropyridine-3-carboxylic acid (2-cyanoethyl) ester was dissolved in 2 ml of methanol. 0.70 ml of 1 N aqueous sodium hydroxide solution was added and stirred at room temperature for 8 hours. After adding 1 N hydrochloric acid and water, precipitates thus formed were taken by the filtration and dried under reduced pressure to obtain the title compound.

Workup

  1. customprecipitates thus
  2. customformed
  3. filtrationwere taken by the filtration
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-727855d407194dd1a0a0f2d031238067
Source dataset
uspto-grants-2007_10
Patent number
US07288544B2

Reaction notes

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