Piperazine → HCID 66863590, compound

HRID 1182839Notes

Reaction equation

HRID 1182839 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:8]2[NH:7][C:6]3[C:11]([O:16][CH2:17][CH3:18])=[N:12][C:13](Cl)=[N:14][C:5]=3[C:4]=2[CH:3]=1.[NH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>C1(C)C=C(C)C=C(C)C=1>[Br:1][C:2]1[CH:10]=[CH:9][C:8]2[NH:7][C:6]3[C:11]([O:16][CH2:17][CH3:18])=[N:12][C:13]([N:19]4[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]4)=[N:14][C:5]=3[C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 58118486HCID 58118486, compound

Product 1

HCID 66863590HCID 66863590, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 7947MesityleneSolvent

Procedure

920 mg (2.9 mmol) 8-bromo-2-chloro-4-ethoxy-5H-pyrimido[5,4-b]indole and 813 mg (9.5 mmol) piperazine were heated in 10 ml mesitylene to 150° C. for 18 h. Then, the solvent was removed and the residue was suspended in water and sucked off. 650 mg (60%) 8-bromo-4-ethoxy-2-(piperazin-1-yl)-5H-pyrimido[5,4-b]indole was obtained. ESI-MS [m/z]: 376, 378 [M+H]+

Workup

  1. customThen, the solvent was removed

Sources & evidence

ORD record
ord-05556104a30d4effafc54055095eaefb
Source dataset
uspto-grants-2014_03
Patent number
US08664233B2

Reaction notes

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