Piperazine → HCID 66863934, compound

HRID 1182843Notes

Reaction equation

HRID 1182843 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[C:6]3[N:14]=[C:13](Cl)[N:12]=[C:11]([O:16][CH2:17][CH3:18])[C:7]=3[NH:8][C:9]=2[CH:10]=1.[NH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>C1(C)C=C(C)C=C(C)C=1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[C:6]3[N:14]=[C:13]([N:19]4[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]4)[N:12]=[C:11]([O:16][CH2:17][CH3:18])[C:7]=3[NH:8][C:9]=2[CH:10]=1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 581185367-bromo-2-chloro-4-ethoxy-5H-pyrimido[5,4-b]indole

Product 1

HCID 66863934HCID 66863934, compound

Reagents, catalysts & solvents 1

HCID 7947MesityleneSolvent

Procedure

5.1 g (15.6 mmol) 7-bromo-2-chloro-4-ethoxy-5H-pyrimido[5,4-b]indole and 13.4 g (155.8 mmol) piperazine were heated in 80 ml mesitylene to 150° C. for 7.5 h. Then, the solvent was removed and the residue was suspended in water and sucked off. 5.8 g (99%) of the title substance was obtained. ESI-MS [m/z]: 376, 378 [M+H]+

Workup

  1. customThen, the solvent was removed
  2. custom5.8 g (99%) of the title substance was obtained

Sources & evidence

ORD record
ord-d1a05cb1c14b43d9b5c83594e20e7608
Source dataset
uspto-grants-2014_03
Patent number
US08664233B2

Reaction notes

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