反应详情

100 mg (0.27 mmol) 7-bromo-4-ethoxy-2-(piperazin-1-yl)-5H-pyrimido[5,4-b]indole (Example 4), 164 μl (1.86 mmol) morpholine, 179 mg (1.59 mmol) KOt-Bu, 1.2 mg (5.4 μmol) Pd(OAc)2 and 4.4 mg (21.6 μmol) P(t-Bu)3 were heated in 6 ml toluene in a microwave oven to 140° C. for 3 h. Then, the solvent was removed and the residue was purified by preparative HPLC (RP18). 8 mg (8%) of the title substance was obtained. ESI-MS [m/z]: 383 [M+H]+

1. customThen, the solvent was removed
2. customthe residue was purified by preparative HPLC (RP18)
3. custom8 mg (8%) of the title substance was obtained