反应详情

温度

120 °C

500 mg (2.11 mmol) of tert-butyl 3-aminopiperidine-1-carboxylate, 772 mg (4.22 mmol) of 2-amino-6-chloro-3-nitropyridine and 1.05 ml (6.34 mmol) of diisopropylethylamine were suspended in 18 ml of DMSO and heated to 120° C. in a microwave reactor for 45 min. The reaction mixture was purified by means of preparative reversed-phase HPLC (method 13). 600 mg (81% of theory) of the product were isolated in solid form.

1. customThe reaction mixture was purified by means of preparative reversed-phase HPLC (method 13)
2. custom600 mg (81% of theory) of the product were isolated in solid form