Water → HCID 86615228, compound

HRID 1183129Notes

Reaction equation

HRID 1183129 reaction equation
C[O:2][C:3](=[O:16])[C@@H:4]([OH:15])[CH2:5][CH2:6][NH:7][C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9].O.[OH-].[Li+:19].O>CO>[C:11]([O:10][C:8]([NH:7][CH2:6][CH2:5][C@H:4]([OH:15])[C:3]([O-:16])=[O:2])=[O:9])([CH3:14])([CH3:12])[CH3:13].[Li+:19]

Participants

5

Reactant 3

HCID 962WaterHCID 168937Lithium hydroxide, monohydrateHCID 54753949HCID 54753949, compound

Product 1

HCID 86615228HCID 86615228, compoundYield 85.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of (S)-4-tert-butoxycarbonylamino-2-hydroxybutyric acid methyl ester (1.52 g, 6.52 mmol) in methanol (20.0 mL) was treated with lithium hydroxide monohydrate (273.8 mg, 6.52 mmol) and water (2.0 mL) for 30 min, concentrated, and dried under vacuum to give a white solid (1.26 g)

Workup

  1. concentrationconcentrated
  2. customdried under vacuum

Sources & evidence

ORD record
ord-f529bf4a32484e3ab191bda420c7a0a2
Source dataset
uspto-grants-2014_03
Patent number
US08664242B2

Reaction notes

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