Hydrochloric Acid → HCID 67361832, compound

HRID 1183185Notes

Reaction equation

HRID 1183185 reaction equation
C[O:2][C:3]([C:5]1[C:9]([F:10])=[C:8]([O:11][CH3:12])[N:7]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[F:19])[N:6]=1)=[O:4].[OH-].[Li+].O.Cl>O1CCOCC1>[F:10][C:9]1[C:5]([C:3]([OH:4])=[O:2])=[N:6][N:7]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[F:19])[C:8]=1[O:11][CH3:12]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 3939Lithium HydroxideHCID 67363585HCID 67363585, compound

Product 1

HCID 67361832HCID 67361832, compoundYield 101.4%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
56 °C

Procedure

70 mg (0.26 mmol) of 4-fluoro-1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid methyl ester were dissolved in 1.3 ml of dioxane and 1.305 ml of a 1 M aqueous solution of lithium hydroxide were added. The mixture was stirred at 56° C. for 30 min, then water and 2 N hydrochloric acid were added and the mixture extracted with diethyl ether. The organic phase was evaporated to give 67 mg (33%) of the title compound.

Workup

  1. extractionthe mixture extracted with diethyl ether
  2. customThe organic phase was evaporated

Sources & evidence

ORD record
ord-1c4d408a7dc94d12b67bc7c1c783f33f
Source dataset
uspto-grants-2014_03
Patent number
US08664257B2

Reaction notes

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