Ethanol → Benzeneacetic acid, hydrazide

HRID 1183417Notes

Reaction equation

HRID 1183417 reaction equation
C[O:2][C:3](=O)[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.CCO.O.[NH2:16][NH2:17]>>[C:5]1([CH2:4][C:3]([NH:16][NH2:17])=[O:2])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Participants

4

Reactant 3

HCID 702EthanolHCID 7559Methyl phenylacetateHCID 24654Hydrazine hydrate (1:1)

Product 1

HCID 70301Benzeneacetic acid, hydrazide

Procedure

Phenyl-acetic acid methyl ester (5 g, 33.3 mmol) was dissolved in hydrazine hydrate (25 mL) and EtOH (50 mL) and the reaction was heated in a sealed tube to 80° C. overnight. After cooling the reaction was concentrated to afford the title compound.

Workup

  1. temperatureAfter cooling the reaction
  2. concentrationwas concentrated

Sources & evidence

ORD record
ord-e77343450d5f47a48e97d4b5d67004de
Source dataset
uspto-grants-2014_03
Patent number
US08664220B2

Reaction notes

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