Benzisothiazole → 3-Chloro-1,2-benzisothiazole

HRID 1183791Notes

Reaction equation

[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[N:2]1.P(Cl)(Cl)([Cl:12])=O.P(Cl)(Cl)Cl>>[Cl:12][C:3]1[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[S:1][N:2]=1

Participants

Reactant 3

HCID 9225Benzisothiazole

HCID 24387Phosphorus trichloride

HCID 24813Phosphorus oxychloride

Product 1

HCID 5981903-Chloro-1,2-benzisothiazole

Procedure

a method including reacting 1,2-benzisothiazole and phosphorus oxychloride or phosphorus trichloride in the absence of a solvent, to give 3-chloro-1,2-benzisothiazole (see, Patent Publication 1):

Sources & evidence

ORD record: ord-f5dd11cf29ff4ed69d53449d4179a5af
Source dataset: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08664404B2

Reaction notes

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