Hydrochloric Acid → 4-(3-Oxopropoxy)benzamide

HRID 1183799Notes

Reaction equation

HRID 1183799 reaction equation
C([O:3][CH:4](OCC)[CH2:5][CH2:6][O:7][C:8]1[CH:16]=[CH:15][C:11]([C:12]([NH2:14])=[O:13])=[CH:10][CH:9]=1)C.Cl>C1COCC1>[O:3]=[CH:4][CH2:5][CH2:6][O:7][C:8]1[CH:16]=[CH:15][C:11]([C:12]([NH2:14])=[O:13])=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 636301464-(3,3-Diethoxypropoxy)benzamide

Product 1

HCID 630404264-(3-Oxopropoxy)benzamideYield 96%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

5 g of the product obtained in Step A, 100 ml of THF and 94 mL of 1N hydrochloric acid solution are added to a flask. The mixture is stirred at ambient temperature for 1 hour. The aqueous phase is extracted with dichloromethane, and then the organic phases are concentrated under reduced pressure. The product is obtained in the form of a solid in a yield of 96% and with a chemical purity of 93%.

Workup

  1. extractionThe aqueous phase is extracted with dichloromethane
  2. concentrationthe organic phases are concentrated under reduced pressure
  3. customThe product is obtained in the form of a solid in a yield of 96% and with a chemical purity of 93%

Sources & evidence

ORD record
ord-5a762a9f0ab244988e35dbd81962e594
Source dataset
uspto-grants-2014_03
Patent number
US08664408B2

Reaction notes

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