Hydrochloric Acid → 5-(3,3-Difluoro-piperidin-1-yl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][c:10]2[cH:11][cH:12][c:13]([I:17])[cH:14][c:15]2[CH2:16]1.[ClH:18].[F:19][C:20]1([F:26])[CH2:21][NH:22][CH2:23][CH2:24][CH2:25]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][c:10]2[cH:11][cH:12][c:13]([N:22]3[CH2:21][C:20]([F:19])([F:26])[CH2:25][CH2:24][CH2:23]3)[cH:14][c:15]2[CH2:16]1Participants
4
Sources & evidence
- ORD record
- ord-d9e6416cdddf465b83674172518470f5
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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