反应详情

温度

20 °C

(2S)-2-{[(Benzyloxy)carbonyl]amino}-2-(3-hydroxyadamantan-1-yl)acetic acid of formula-XIV (20 gm), (1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carbonitrile PTSA salt of Formula-XIII (16 gm), 1-ethyl-3-(3-dimethylaminoporpyl)carbodiimide (12 gm) and 1-hydroxy benzotriazole (1.2 gm) were dissolved in ethyl acetate (20 ml) and acetonitrile (40 ml). The reaction mixture was cooled to 20° C. Then addition of N,N-diisopropylethylamine (16 gm) was carried out for 15 min. The reaction mixture was stirred for 8 hrs and washed with 2N HCl solution. Organic phase was washed with NaHCO3 solution, dried and evaporated to yield 19.8 gm (80%) of title product. MP: 105-106° C.

1. washwashed with 2N HCl solution
2. washOrganic phase was washed with NaHCO3 solution
3. customdried
4. customevaporated