Ethylamine → HCID 86680541, compound

HRID 1184622Notes

Reaction equation

HRID 1184622 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3](O)=O.CS(O[CH:13]([C:35]1[CH:40]=[CH:39][C:38](C(F)(F)F)=C[CH:36]=1)[C:14]([N:16]1[CH2:21][CH2:20][N:19]2[CH2:22][C@H:23]([O:25][C:26]3[CH:31]=[N:30][C:29]([CH:32]4[CH2:34][CH2:33]4)=[CH:28][N:27]=3)[CH2:24][C@H:18]2[CH2:17]1)=[O:15])(=O)=O.[F:45][CH2:46][CH2:47][NH2:48].C(N)C>>[CH:32]1([C:29]2[N:30]=[CH:31][C:26]([O:25][C@H:23]3[CH2:22][N:19]4[CH2:20][CH2:21][N:16]([C:14](=[O:15])[CH:13]([NH:48][CH2:47][CH2:46][F:45])[C:35]5[CH:40]=[CH:39][CH:38]=[C:3]([C:2]([F:7])([F:6])[F:1])[CH:36]=5)[CH2:17][C@@H:18]4[CH2:24]3)=[N:27][CH:28]=2)[CH2:34][CH2:33]1

Participants

5

Reactant 4

HCID 6341EthylamineHCID 6422Trifluoroacetic acidHCID 99962-FluoroethylamineHCID 86680539HCID 86680539, compound

Product 1

HCID 86680541HCID 86680541, compound

Procedure

The title compound was prepared as a trifluoroacetic acid salt according to the procedure described in Example 194B, substituting the product from Example 179A for the product from Example 194A, and substituting 2-fluoroethanamine for ethylamine 1H NMR (300 MHz, CDCl3) δ ppm 0.88-1.06 (m, 4 H) 4.62-4.77 (m, 1 H) 4.78-4.93 (m, 1 H) 5.42-5.71 (m, 1 H) 7.63-7.76 (m, 3 H) 7.77-7.86 (m, 1 H) 7.88-7.95 (m, 1 H) 7.98-8.14 (m, 1 H); MS (ESI) m/z 508 (M+H)+.

Sources & evidence

ORD record
ord-36479d1e20444db3ad7c308bfb700af0
Source dataset
uspto-grants-2014_03
Patent number
US08669255B2

Reaction notes

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