Hydrochloric Acid → Ethyl 2-(furan-2-yl)quinoline-4-carboxylate

HRID 1185438Notes

Reaction equation

HRID 1185438 reaction equation
Cl.[O:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]1[CH:16]=[C:15]([C:17]([OH:19])=[O:18])[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=1.[C:20]1(C)C=CC=C[CH:21]=1>C(O)C>[CH2:20]([O:18][C:17]([C:15]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[C:7]([C:3]2[O:2][CH:6]=[CH:5][CH:4]=2)[CH:16]=1)=[O:19])[CH3:21]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 1140TolueneHCID 6976402-(Furan-2-yl)quinoline-4-carboxylic acid

Product 1

HCID 27000068Ethyl 2-(furan-2-yl)quinoline-4-carboxylate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To 40 ml of a saturated solution of hydrochloric acid in ethanol 2 g of 2-Furan-2-yl-quinoline-4-carboxylic acid was added and the mixture was heated to reflux for 3 h. Then, after cooling to RT, 30 ml of toluene was added and the solvents were removed under reduced pressure. The obtained crude product was pure enough for the next reaction step. Yield: 2.5 g.

Workup

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 3 h
  3. customthe solvents were removed under reduced pressure
  4. customThe obtained crude product
  5. customwas pure enough for the next reaction step

Sources & evidence

ORD record
ord-d5671b8c2b414fc28a2b84e0a9f1bd62
Source dataset
uspto-grants-2014_03
Patent number
US08669266B2

Reaction notes

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