Trifluoroacetic acid → HCID 178452374, compound

HRID 1185576Notes

Reaction equation

HRID 1185576 reaction equation
[CH2:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:32])[C@@H:15]([NH:24]C(OC(C)(C)C)=O)[CH2:16][C:17]2[C:18]([OH:23])=[N:19][O:20][C:21]=2[CH3:22])[CH2:10][CH2:9]1)=[O:7])[CH2:2][CH2:3][CH3:4].C(O)(C(F)(F)F)=O>ClCCl>[CH2:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][N:11]([C:14](=[O:32])[C@@H:15]([NH2:24])[CH2:16][C:17]2[C:18]([OH:23])=[N:19][O:20][C:21]=2[CH3:22])[CH2:12][CH2:13]1)=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178452368HCID 178452368, compound

Product 1

HCID 178452374HCID 178452374, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 146 mg 4-[(S)-2-tert-Butoxycarbonylamino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)-propionyl]-piperazine-1-carboxylic acid butyl ester in 5 ml dichloromethane were added 0.4 ml TFA. After 12 h stirring at RT the solvents were removed and the residue was codistilled twice with toluene. Yield: 156 mg.

Workup

  1. customwere removed

Sources & evidence

ORD record
ord-d70357cc525a4bce91a06e0a920a8846
Source dataset
uspto-grants-2014_03
Patent number
US08669266B2

Reaction notes

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