Tetrahydrofuran → HCID 46786364、化合物

HRID 1185967ノート

反応式

HRID 1185967 の反応式
[CH3:1][O:2][C:3](=[O:17])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-])=O)=[CH:7][C:6]=1[N+:14]([O-])=O.O1CCCC1.[BH4-].[Na+].[Cl-].[Cl-].[Cl-].[Al+3]>O>[CH3:1][O:2][C:3](=[O:17])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][C:6]=1[NH2:14]

参加物

6

反応物 4

HCID 8028TetrahydrofuranHCID 286146Methyl 2-(2,4-dinitrophenyl)acetateHCID 4311764Sodium borohydrideHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 46786364HCID 46786364、化合物収率 101.1%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

The obtained 2,4-dinitrophenylacetic acid methyl ester (2.28 g) was added into tetrahydrofuran (50 ml), and was dissolved by stirring at room temperature. Sodium borohydride (0.76 g, 0.02 mole) and aluminum trichloride (1.33 g, 0.01 mole) were then added, and reaction was conducted for 2 hours at room temperature. After the reaction, water (10 ml) was added to completely react with the remaining reductant. Solvent was removed by distilling under a reduced pressure to obtain 2,4-diaminophenylacetic acid methyl ester (1.73 g, yield: 90%).

後処理

  1. dissolutionwas dissolved
  2. customreaction
  3. additionwas added
  4. customto completely react with the remaining reductant
  5. customSolvent was removed
  6. distillationby distilling under a reduced pressure

出典と根拠

ORDレコード
ord-922b24a1362e48399b7b96a745e17e4f
出典データセット
uspto-grants-2014_03
特許番号
US08673177B2

反応ノート

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