反应详情

According to Reference Example 8-2, by use of 1-(cyclopropylmethyl)-1H-imidazole-5-carbaldehyde (212 mg, 1.41 mmol) dissolved in N,N-dimethylformamide (4.2 mL), potassium carbonate (39 mg, 0.28 mmol) and (trifluoromethyl)trimethylsilane (0.626 mL, 4.23 mmol), the mixture was stirred and reacted at room temperature for 2 hours. Then, purification by preparative thin-layer chromatography (chloroform/methanol=12/1) was performed to give 1-[1-(cyclopropylmethyl)-1H-imidazol-5-yl]-2,2,2-trifluoroethanol (Compound DW) (206 mg, yield: 66%).

1. customreacted at room temperature for 2 hours
2. customThen, purification by preparative thin-layer chromatography (chloroform/methanol=12/1)