反应详情

According to Reference Example 8-2, by use of 1-(cyclopropylmethyl)-1H-imidazole-4-carbaldehyde (133 mg, 0.886 mmol) obtained in Step 1 of Reference Example 8-49 and dissolved in N,N-dimethylformamide (2.7 mL), potassium carbonate (24 mg, 0.18 mmol) and (trifluoromethyl)trimethylsilane (0.196 mL, 1.33 mmol), the mixture was stirred and reacted at room temperature for 2 hours. Then, purification by preparative thin-layer chromatography (chloroform/methanol=15/1) was performed to give 1-(1-(cyclopropylmethyl)-1H-imidazol-4-yl)-2,2,2-trifluoroethanol (Compound DX) (85.2 mg, yield: 44%).

1. customreacted at room temperature for 2 hours
2. customThen, purification by preparative thin-layer chromatography (chloroform/methanol=15/1)