Aluminium lithium hydride → HCID 64666716, compound

HRID 1186395Notes

Reaction equation

HRID 1186395 reaction equation
[CH3:1][CH:2]([CH2:8][C:9]1[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=1)[C:3](OCC)=[O:4].[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH3:1][CH:2]([CH2:8][C:9]1[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=1)[CH2:3][OH:4]

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 67401446HCID 67401446, compound

Product 1

HCID 64666716HCID 64666716, compoundYield 101.8%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

According to Step 2 of Reference Example 8-63, tetrahydrofuran (10 mL) and a solution prepared by dissolving, in tetrahydrofuran (5 mL), ethyl 2-methyl-3-(pyridin-3-yl)propanoate (200 mg, 1.0 mmol) obtained in Step 2 of Reference Example 8-65 were added to lithium aluminum hydride (75 mg, 2.0 mmol), and the mixture was stirred with cooling in an ice bath for 1 hour. Thus, 2-methyl-3-(pyridin-3-yl)propan-1-ol (Compound EM) (154 mg, yield: 99%) was obtained.

Workup

  1. customa solution prepared
  2. temperaturewith cooling in an ice bath for 1 hour

Sources & evidence

ORD record
ord-a2928879e5c44fa494473900b05c50b1
Source dataset
uspto-grants-2014_03
Patent number
US08673908B2

Reaction notes

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